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KMID : 0043320040270121295
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Archives of Pharmacal Research
2004 Volume.27 No. 12 p.1295 ~ p.1301
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Enantioseparation of Flurbiprofen and Ketoprofen in Patches and in Urine Excretions by Achiral Gas Chromatography
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Paik Man-Jeong
Nguyen Duc-Toan
Kim Kyoung-Rae
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Abstract
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The enantiomeric composition tests on flurbiprofen and ketoprofen present in patch products and in urine excretions following patch applications were performed as diastereomeric (R)-(+)- 1-phenylethylamides by achiral gas chromatography and by gas chromatography-mass spectrometry in selected ion monitoring mode. The method for determination of (R)- and (S)-enantiomers in the range from 0.1 to 5.0 g was linear (r 0.9996) with acceptable precision (% RSD 5.2) and accuracy (% RE = 0.6 ~ -2.4). The enantiomeric compositions of flurbiprofen in one patch product and of ketoprofen in five different products were identified to be racemic with relatively good precision ( 6.4%). The urinary excretion level of (R)-flurbiprofen was two times higher than its antipode, while the comparable excretion levels of (R)- and (S)-enantiomers for ketoprofen were observed.
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KEYWORD
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Enantioseparation, Flurbiprofen, Ketoprofen, Patch, Gas chromatography, Gas chromatography-mass spectrometry in selected ion monitoring
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